By Robert Engel
Synthesis of Carbon-Phosphorus Bonds, moment version is a operating advisor for the laboratory, incorporating classical techniques with the new advancements of carbon-phosphorus (C-P) bond formation. those advances contain the education of phosphoranes -- in particular within the use of temporary oxophosphoranes as intermediates in organophosphorus compound synthesis ñ in addition to the recent ways in the direction of the guidance of compounds with fragrant and vinylic C-P bonds.Synthesis of Carbon-Phosphorus Bonds, moment version serves as a useful gizmo within the laboratory. It bargains special surveys of IUPAC nomenclature thoughts, universal notation platforms, and diverse experimental examples. those good points support to make this article an efficient resource of severe and annotated references, in addition to a a operating advisor for natural and phosphorus chemists particularly, or for any chemists operating with C-P bonds.
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Synthesis of Carbon-Phosphorus Bonds, moment version is a operating consultant for the laboratory, incorporating classical methods with the new advancements of carbon-phosphorus (C-P) bond formation. those advances contain the practise of phosphoranes -- particularly within the use of temporary oxophosphoranes as intermediates in organophosphorus compound synthesis ñ besides the hot techniques in the direction of the coaching of compounds with fragrant and vinylic C-P bonds.
Extra resources for Synthesis of carbon-phosphorus bonds
9. F. , Direct determination of elemental phosphorus by gas-liquid chromatography, J. , 48, 421, 1970. 10. M. , Synthesis of sodium hypophosphite solutions, Zh. Prikl. , 40, 1660, 1967. 11. V. , Hypophosphorous acid and its salts, Usp. , 44, 2150, 1975. 12. , Hypophosphites and their reactivity, Usp. , 49, 92, 1980. 13. A. , The reactivity behavior of P4 molecules and especially its “slow” reaction to give primary reaction products with oxidation levels between zero and three, Pure Appl. , 52, 905, 1980.
01 mol) in 57% aqueous HI (3 ml). The mixture was heated under reflux for 6 h. fm Page 22 Wednesday, November 19, 2003 10:56 AM to dryness under vacuum. The residue was dissolved in water that was then extracted with diethyl ether. The aqueous layer was concentrated to dryness, and the residue was recrystallized from 2-propanol/acetone to give the product benzylphosphonic acid in 25% yield. 8 Summary We have not been concerned with an attempt to be encyclopedic here. Rather, we are looking to provide: 1.
29 Difficulties can arise as a result of the normal generation of a haloalkane species by-product during the second step of the reaction; the thus-generated haloalkane may itself be able to undergo reaction with the trivalent phosphorus reagent giving undesired side products. These side products can occur particularly when the ester linkage of the trivalent phosphorus reagent is related to a methyl or other primary haloalkane or the halide reagent is a secondary aliphatic halide. One approach to avoiding this difficulty involves strongly heating the halide reagent using a minimally cooled condenser and slowly adding the phosphorus reagent.
Synthesis of carbon-phosphorus bonds by Robert Engel