Harold C. Smith's RNA and DNA Editing: Molecular Mechanisms and Their PDF

By Harold C. Smith

ISBN-10: 0470109912

ISBN-13: 9780470109915

RNA and DNA enhancing assembles a workforce of top specialists who current the most recent discoveries within the box along the newest types and method. additionally, the authors set forth the various open questions and recommend routes for additional research. total, the ebook serves as a realistic consultant for execs within the box who have to comprehend the interrelationship of RNA and DNA modifying with different chemical and organic methods.

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Extra resources for RNA and DNA Editing: Molecular Mechanisms and Their Integration into Biological Systems

Sample text

Comparison between wild-type and ADAR-/- cDNA array data led to the identification of 500 putative ADAR target genes (104). In addition, a database search was performed in which Drosophila cDNA sequences were compared to their genomic counterparts, as a genomically encoded adenosine will appear as guanosine in the expressed sequence after editing. This resulted in the detection of 800 genes that show an A/G discrepancy within the coding region. Ultimately, by comparing these two groups of putative editing targets, 62 genes were present in both groups.

This more recently reported editing site in humans stands out because the premRNA that undergoes modification does not contain introns, which means that the partially base-paired RNA fold-back structure is comprised entirely of exonic sequences (41). 3 below). 2), for which there are currently no experimental data available regarding the physiological impact of editing (38–41). Interestingly, they also include non-neuronal transcripts. In addition, a few examples exist where recoding events are predicted from A/G discrepancies that are only detected in transcripts derived from pathological tissues or cells, such as cancer (prox1, PCNP) and lupus erythematosus (60).

The initial discovery of adenosine-modification editing quickly led to the identification of several other cases of recoding in nervous-system-specific transcripts, such as additional GluRs (7, 8) and 5HT2C-R (9). In each case a single nucleotide change resulting in an amino acid substitution could be linked to a change in protein function. Since unedited and edited protein variants often are co-expressed in the same cells RNA editing was soon recognized as a potentially important mechanism to diversify genetic information with the ability to enhance the complexity of the eukaryotic transcriptome and proteome.

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RNA and DNA Editing: Molecular Mechanisms and Their Integration into Biological Systems by Harold C. Smith


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