Download PDF by M. B. Chenoweth (auth.), Maynard B. Chenoweth (eds.): Modern Inhalation Anesthetics

By M. B. Chenoweth (auth.), Maynard B. Chenoweth (eds.)

ISBN-10: 3642650554

ISBN-13: 9783642650550

ISBN-10: 3642650570

ISBN-13: 9783642650574

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DUNCAN (1959) and BURNS and SNOW (1961) modified the method, using lithium aluminum hydroxide and dispersed sodium respectively. These modifications improved the recovery rate as well as ease of analytical procedures. However, studies on pharmacokinetics of halothane depend upon rapid and accurate measurement of vapor concentrations. Evaluation of various clinical vaporizers would be difficult and cumbersome without using some physical methods of measurement. KALOW (1957) first determined the ultraviolet and infrared spectra of halothane vapor using a spectrophotometer.

Pharmacol. Exptl Therap_ 108,488-495 (1953). LARSEN, E. : Unpublished results (1959). - The chemistry of methoxyflurane. Paper presented at the 140th Meeting of the American Chemical Society, Chicago, Illinois, September 3-8, (1961). - 2-bromo-1,1,t,2-tetrafluoroethane. S. Patent 2,971,990 (1961). - Unpublished results (1962). - (1) Inhalation anesthetic: 2,2-dichloro-1,1-difluoroethyl methyl ether. S. Patent 3,104,202 (1963). - (2) Hydrolysis of fluorinated ethers. J. Org. Chem. 28, 1133 (1963).

CHgOH + CHaCHO . BELL and KRANTZ (1953) showed that trifluoroethyl vinyl ether is readily brominated in aqueous solution. LINDE (1956) took advantage of this ease of bromination to develop a method of analyzing the concentration of fluroxene in blood. In Linde's procedure the blood sample is steam distilled and the distillate is collected in a dilute solution of bromine in methanol. Potassium iodide is then added and titrated with sodium thiosulfate. As little as 1 mg offluroxene is detectable by this method.

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Modern Inhalation Anesthetics by M. B. Chenoweth (auth.), Maynard B. Chenoweth (eds.)


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