By Minghan Wang
This publication offers a entire review of the improvement of metabolic syndrome, the underlying mechanisms and healing concepts for drug improvement. The authors research the context of underlying molecular pathways and built-in body structure, then increasing the dialogue to ailments linked to metabolic syndrome. the advance of drug remedies for those illnesses and problems is commonly lined. The e-book deals a finished and in-depth view of strength metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and medical implications.
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Extra resources for Metabolic Syndrome: Underlying Mechanisms and Drug Therapies
KELLETT. 2007. Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J Physiol 582:379–392; erratum in J Physiol 583:411. 38. , and D. DRENCKHAHN. 1998. Identification of the taste cell G-protein, alpha-gustducin, in brush cells of the rat pancreatic duct system. Histochem Cell Biol 110:303–309. 39. , B. PUSCHEL, and D. DRENCKHAHN. 1996. Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin. Proc Natl Acad Sci USA 93:6631–6634.
Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia 48:2236–2240. 151. B. J. C. L. V. LLOYD. 2005. Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery. N Engl J Med 353:249–254. 152. D. J. ZINNER. 2006. Post-gastric bypass hyperinsulinism with nesidioblastosis: subtotal or total pancreatectomy may be needed to prevent recurrent hypoglycemia. J Gastrointest Surg 10:1116–1119.
Although the mechanisms behind the antidiabetic effect are not entirely clear, increased insulin secretion and improved b-cell function are likely involved. Lateonset hyperinsulinemic hypoglycemia has been observed in patients after the surgery (150–152), and some may even require partial or total pancreatectomy to prevent recurrent hypoglycemia (150, 152). This phenomenon underscores the robust improvement of pancreatic function achieved by RYGB. GLP-1 and PYY are two important gut hormones that are believed to mediate the more robust beneficial effects of RYGB compared to LAGB, a procedure that restricts food intake by banding the stomach but does not involve the bypass of the proximal intestine.
Metabolic Syndrome: Underlying Mechanisms and Drug Therapies by Minghan Wang