Get Melanoma Development: Molecular Biology, Genetics and PDF

By Anja Bosserhoff, Luigi Strizzi (auth.), Anja Bosserhoff (eds.)

ISBN-10: 3709103703

ISBN-13: 9783709103708

ISBN-10: 3709103711

ISBN-13: 9783709103715

The e-book presents finished insights into molecular alterations in malignant cancer. the final mechanisms of cancer development and improvement are defined, in addition to new study findings. Our present wisdom at the molecules excited about telephone transformation and tumor development will quickly bring about refined, particular remedies. fresh reviews with detailed b-RAF inhibitors have given us grounds to wish that those treatments can be profitable. cancer improvement- Molecular Biology, Genetics and scientific software goals to give a contribution to this information. Summarizing the most recent information and providing upcoming learn parts within the box, the publication could be of serious curiosity to easy researchers and physicians operating within the very important fields of cancer, melanoma learn, treatment and dermatology.

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Melanoma Development: Molecular Biology, Genetics and by Anja Bosserhoff, Luigi Strizzi (auth.), Anja Bosserhoff PDF

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Additional info for Melanoma Development: Molecular Biology, Genetics and Clinical Application

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1997), and might involve the activation of Akt, as was shown for endothelial NO synthase (Dimmeler et al. 1999). The melanogenic effect of UV was abrogated to a large extent upon treatment with NO scavengers, while treatment of melanocytes with exogenous NO donors stimulated melanogenesis and dendricity, lending direct evidence for the melanogenic effect of NO (Romero-Graillet et al. 1997). This effect was mediated by increasing the levels of cGMP, and treatment of melanocytes with guanylate cyclase inhibitiors blocked the UV-induced melanogenesis (Romero-Graillet et al.

Swope McGowan KA, Li JZ, Park CY, Beaudry V, Tabor HK, Sabnis AJ, Zhang W, Fuchs H, de Angelis MH, Myers RM, Attardi LD, Barsh GS (2008) Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat Genet 40:963–970 Medrano EE, Im S, Yang F, Abdel-Malek Z (1995) UVB light induces G1 arrest in human melanocytes by prolonged inhibition of pRb phosphorylation associated with long term expression of the protein p21Waf-1/SDI/Cip-1 protein. Cancer Res 55:4047–4052 Morelli JG, Yohn JJ, Lyons MB, Murphy RC, Norris DA (1989) Leukotrienes C4 and D4 as potent mitogens for cultured human melanocytes.

Pigment Cell Melanoma Res 21:464–470 Bronner-Fraser M (1993) Neural development: crest destiny. Curr Biol 3:201–203 Bustamante J, Bredeston L, Malanga G, Mordoh J (1993) Role of melanin as a scavenger of active oxygen species. Pigment Cell Res 6:348–353 Candille SI, Kaelin CB, Cattanach BM, Yu B, Thompson DA, Nix MA, Kerns JA, Schmutz SM, Millhauser GL, Barsh GS (2007) A {beta}-defensin mutation causes black coat color in domestic dogs. 1126/science. 1147880 Chakraborty AK, Funasaka Y, Slominski A, Ermak G, Hwang J, Pawelek JM, Ichihashi M (1996) Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B.

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Melanoma Development: Molecular Biology, Genetics and Clinical Application by Anja Bosserhoff, Luigi Strizzi (auth.), Anja Bosserhoff (eds.)


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