By A.A. Moscona and Alberto Monroy (Eds.)
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The beta cells of the pancreatic islets of Langerhans are the single cells within the physique that produce and secrete insulin. This metabolic hormone performs a principal function within the upkeep of glucose homeostasis, regulating glucose uptake in muscle and adipose tissue in addition to carbohydrate, fats, and protein metabolism in those tissues and the liver.
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Whether these behaviors of sir- mutants reflect alterations of the normal process or superimposing of an unnatural pathway of switching remains to be determined. One additional level of control of the switching process is known: switching occurs in a and a cells but not in a h cells. Because switching 1. CELLULAR DIFFERENTIATION IN YEAST 11 occurs in a/a and a h cells, the block in a/a cells is not due to diploidy per se. , 1979). The basis for the inhibition of switching has recently been determined and is rather simple: the H O gene product is not made in a h cells.
Genome Function, Cell Interactions, and Differentiation by A.A. Moscona and Alberto Monroy (Eds.)