By M. Volkenstein (Auth.)
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This can also substantially limit the speed of changing the primary structure of histones in the process of evolution. The data on the structure of histones are cited in various publications [110, 111]. Histones apparently form salt bonds with D N A - p h o s p h a t e groups. 3/1, and the average number of basic groups of histones is approximately equal to the number of phosphate groups in the D N A bonded with them. Presumably, helical regions of histones are located in the groove of the D N A double helix; nonhelical and nonbasic residues form loops .
The general physical principles of regulation, however, have been charted. At the same time, the established facts make it possible to begin the elaboration of physicomathematical models of regulation processes (see Chapter 9). References* 1. M. " Academic Press, New York, 1977. 2. M. " Wiley-Interscience, New York, 1963. 3. T. Birstein and O. " Wiley-Interscience, New York, 1966. 4. P. " Wiley-Interscience, New York, 1969. 5. M. " Nauka, Moscow, 1967 (R). 6. F. , 1962. 7. R. Cecil and J. McPhee, Adv.
If the signaling is cooperative, aggregation brings about a characteristic flux similar to that of some myxomycètes. A detailed experimental study of the aggregation of chicken embryo cells has been carried out  wherein it has been possible to extract the macromolecular factors promoting aggregation and to insert radioactive labels into them. It turns out that these substances are specifically bound by definite tissues. There apparently exist specific receptors on the surfaces of the cells, that is, recognizing factors that promote aggregation.
General Biophysics by M. Volkenstein (Auth.)