Download e-book for iPad: Fundamentals of molecular virology by Nicholas H. Acheson

By Nicholas H. Acheson

ISBN-10: 0470900598

ISBN-13: 9780470900598

This new, totally revised moment version of Fundamentals of Molecular Virology is designed for college scholars studying approximately virology on the undergraduate or graduate point. Chapters hide lots of the significant virus households, emphasizing the original beneficial properties of every virus family members. those chapters are designed to inform tales concerning the viruses lined, and contain details on discovery, ailments and pathogenesis, virus constitution, steps in viral replication, and interplay with mobile signaling pathways. This process portrays the “personality” of every virus, aiding scholars to benefit the cloth and to accumulate their wisdom of virology, beginning with smaller and easier viruses and continuing to extra complicated viruses.

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Early viral genes are expressed: the Baltimore classification of viruses Once in the appropriate compartment of the cell, the viral genome must direct expression of “early” proteins that will enable genome replication. The molecular pathways that lead to synthesis of early viral proteins from viral messenger RNAs depend on the chemical nature and strandedness of the genome. 7). One advantage of this system is that it draws our attention to the distinct kinds of RNA polymerases needed by viruses in each group, and indicates whether these enzymes are available in the cell or must be provided by the virus.

This makes red blood cells an ideal substrate for assaying viruses. Virus particles have multiple copies of receptorbinding proteins on their surface, and red blood cells contain many copies of surface receptors. Binding between an excess of virus particles and an aliquot of red blood cells forms an interlaced network of cells, held together by virus particles that form bridges between adjacent cells. These “agglutinated” red blood cells, when allowed to settle, form a light pink hemispherical shell in the bottom of a tube or plastic well.

There are 10–50 million bacteriophages on average per mL of seawater, and even more in many soils. Given the enormous volume of the oceans, scientists have calculated that there may be as many as 1031 bacteriophages in the world. This is about 10-fold greater than the estimated number of bacteria. In terms of mass, this many phages would weigh about 100 million tons, or the equivalent of 1 million blue whales (the largest animal on Earth). More astonishing, these 1031 phages, if lined up head-to-tail, would stretch some 200 million light years into space—that is, far into the universe beyond many of our known neighboring galaxies (see text box on page 6)!

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Fundamentals of molecular virology by Nicholas H. Acheson


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