By John H. Byrne, Ruth Heidelberger, M. Neal Waxham
An knowing of the frightened procedure at almost any point of study calls for an realizing of its uncomplicated development block, the neuron. The 3rd version of From Molecules to Networks offers the forged beginning of the morphological, biochemical, and biophysical homes of nerve cells. in accordance with past variants, the original content material specialise in mobile and molecular neurobiology and comparable computational neuroscience is maintained and greater.
All chapters were completely revised for this 3rd version to mirror the numerous advances of the earlier 5 years. the recent variation expands at the community points of mobile neurobiology by way of including new insurance of particular learn tools (e.g., patch-clamp electrophysiology, together with purposes for ion channel functionality and transmitter free up; ligand binding; structural equipment reminiscent of x-ray crystallography).
Written and edited by means of major specialists within the box, the 3rd version thoroughly and comprehensively updates all chapters of this designated textbook and insures that each one references to basic study characterize the newest results.
* the 1st remedy of mobile and molecular neuroscience that comes with an advent to mathematical modeling and simulation approaches
* eighty% up-to-date and new content material
* New bankruptcy on "Biophysics of Voltage-Gated Ion Channels"
* New bankruptcy on "Synaptic Plasticity"
* encompasses a bankruptcy at the Neurobiology of Disease
* hugely referenced, finished and quantitative
* complete colour, expert pics throughout
* All photos are available digital model for educating purposes
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Extra resources for From Molecules to Networks, Third Edition: An Introduction to Cellular and Molecular Neuroscience
Cortex. 3, 361À372. , 1995. Neuroglia. Oxford University Press, Oxford. , 2008. Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations. Science. 321, 53À57. , 2003. Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo. Nature. 421, 844À848. , 2011. Selective coexpression of multiple chemical markers defines discrete populations of neocortical GABAergic neurons. Cereb. Cortex. 21, 1803À1817. , 2011. The neurovascular unit in brain function and disease.
Some molecules cross the BBB by clathrin-mediated endocytosis. However, in addition to clathrin-mediated transport, the plasma membranes of brain endothelia are enriched in membrane lipid rafts, called caveolae, that participate in potocytosis, a type of endocytosis by which small molecules are transported across the plasma membrane by caveolae rather than clathrin-coated vesicles. Select plasma proteins are, for example, taken up and transported across endothelial cell membranes by both receptor-mediated and receptor-independent transcytosis (transport across the interior of the cell from blood to interstitial fluid or vice versa) involving caveolae.
Am. J. Physiol. 267, L223ÀL241. , 2010. Myelination and the trophic support of long axons. Nat. Rev. Neurosci. 11, 275À283. , 1999. A brief history of myelinated nerve fibers: one hundred and fifty years of controversy. J. Neurocytol. 28, 251À262. I. CELLULAR AND MOLECULAR This page intentionally left blank C H A P T E R 2 Subcellular Organization of the Nervous System Organelles and Their Functions Scott Brady, David R. Colman and Peter Brophy AXONS AND DENDRITES: UNIQUE STRUCTURAL COMPONENTS OF NEURONS Cells have many features in common, but each cell type also possesses a functional architecture related to its unique physiology.
From Molecules to Networks, Third Edition: An Introduction to Cellular and Molecular Neuroscience by John H. Byrne, Ruth Heidelberger, M. Neal Waxham