Read e-book online Free-Radical-Induced DNA Damage and Its Repair PDF

By Clemens Sonntag

ISBN-10: 3642065546

ISBN-13: 9783642065545

Figuring out of the molecular foundation of DNA harm and its fix has elevated dramatically lately, and significant wisdom now exists about the items coming up from free-radical assault on DNA. Free-radical DNA harm could lead to mutations, melanoma, and cellphone dying. loose radicals have a number of assets, significantly ionizing radiation and oxidative tension. In radiotherapy for melanoma and with a few anticancer medications, use is made up of phone dying through over the top DNA harm. The mechanisms resulting in items of free-radical assault that have been studied in versions and with small double-stranded DNA fragments are mentioned intimately, and the fundamentals of the underlying free-radical chemistry are handled in separate chapters.

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J Chem Soc Perkin Trans 2 1689–1696 Ellis KV (1991) Water disinfection: a review with some consideration of the requirements of the third world. Crit Rev Env Contr 20:341–407 Engelmann MD, Bobier RT, Hiatt T, Cheng IF (2003) Variability of the Fenton reaction characteristics of the EDTA, DTPA and citrate complexes of iron. BioMetals 16:519–527 Epsztejn S, Kakhlon O, Glickstein H, Breuer W, Cabantchik I (1997) Fluorescence analysis of the labile iron pool of mammalian cells. Anal Biochem 248:31–40 Faraggi M, Hemmerich P, Pecht I (1975) O2-affinity of flavin radical species as studied by pulse radiolysis.

2 Copper There are a number of transition-metal ions in low oxidation states such as Cu(I) which readily react with H2O2. , is capable of abstracting an H atom from MeOH. At high MeOH concentration the chain length of this reaction depends on the MeOH concentration, and it has thus been concluded that an oxidant must be present which has not the properties of free • OH (Johnson et al. 1985, 1988). Evidence has been given that the intermediate, (H2O)mCu+−O2H− can decompose in acid solution into Cu2+ and • OH, but at sufficiently high Hdonor concentration also react with the latter (Masarwa et al.

1993; Saito et al. 1995, 1997; Saito and Takayama 1995; Sugiyama and Saito 1996; Ly et al. 1996; Gasper and Schuster 1997; Nakatani et al. 1998; Kino and Saito 1998), especially with intercalated quinones, non-selective DNA cleavage can occur with free H-abstracting quinones (Breslin and Schuster 1996). It may be mentioned here that 1,4-benzoquinone, and some other quinones, undergo a reaction with water (for details see von Sonntag et al. 2004), and these competitive reactions may have to be taken into account when using quinones as photosensitizer.

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Free-Radical-Induced DNA Damage and Its Repair by Clemens Sonntag


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