Download PDF by Graeme Milligan, Ikuo Kimura: Free Fatty Acid Receptors

By Graeme Milligan, Ikuo Kimura

ISBN-10: 3319506927

ISBN-13: 9783319506920

ISBN-10: 3319506935

ISBN-13: 9783319506937

This e-book highlights the $64000 position unfastened fatty acids (FFA) play as power drug pursuits. whereas FFA have lengthy been thought of byproducts of cellphone metabolism, they're now well-known as ligands that control telephone and tissue functionality through G-protein-coupled receptors. at the least 3 receptors were pointed out for which FFA seem to be the endogenous ligands.

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Extra resources for Free Fatty Acid Receptors

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The authors found that FFA4 stimulates and FFA1 inhibits motility, invasion and tumorigenicity of pancreatic cancer cells. Using the same tools, the group has also studied the effects of FFA4 and FFA1 on ethionine induced liver epithelial cell motility (WB-F344 cells) and the role of the receptors in several lung cancer cell lines (Ishii et al. 2015a, b; Kita et al. 2016). Kim et al. reported that FFA4 negatively regulates osteoclast differentiation, survival, and function, by using GW9508 as an FFA4 probe despite expression of FFA1 at a very low level, and provided support for the conclusion through the use of shRNA-mediated FFA4 knockdown (Kim et al.

3 Antagonists . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Outlook . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 34 37 39 39 46 48 48 52 Abstract The free fatty acid receptor 4 (FFA4), also known as GPR120, is a G proteincoupled receptor that is activated by long-chain fatty acids and that has been associated with regulation of appetite, release of insulin controlling hormones, insulin sensitization, anti-inflammatory and potentially anti-obesity activity, and is progressively appearing as an attractive potential target for the treatment of metabolic dysfunctions such as obesity, type 2 diabetes and inflammatory disorders.

5 Outlook . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 34 37 39 39 46 48 48 52 Abstract The free fatty acid receptor 4 (FFA4), also known as GPR120, is a G proteincoupled receptor that is activated by long-chain fatty acids and that has been associated with regulation of appetite, release of insulin controlling hormones, insulin sensitization, anti-inflammatory and potentially anti-obesity activity, and is progressively appearing as an attractive potential target for the treatment of metabolic dysfunctions such as obesity, type 2 diabetes and inflammatory disorders.

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Free Fatty Acid Receptors by Graeme Milligan, Ikuo Kimura


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