Download e-book for iPad: Fatty Acids and Lipotoxicity in Obesity and Diabetes: by Novartis Foundation

By Novartis Foundation

ISBN-10: 0470057645

ISBN-13: 9780470057643

ISBN-10: 0470985577

ISBN-13: 9780470985571

The aptitude lipotoxic impact of accumulation of fatty acids in non-adipose tissues is assumed to be a tremendous part within the improvement of insulin resistance. persistent publicity to excessive concentrations of loose fatty acids within the blood impacts pancreatic ? phone functionality, insulin secretion and lipid synthesis within the liver, and garage in adipose tissue. holding the traditional degrees of fatty acids calls for coordinated law among the liver, adipose tissue and skeletal muscle.

This ebook bargains with the molecular points of fatty acid motion in weight problems and insulin resistance. the subjects comprise lipid metabolism and adipose tissue biology, and ? cellphone functionality and insulin resistance. Chapters care for the molecular genetics and molecular body structure of power homeostasis.Content:

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Additional info for Fatty Acids and Lipotoxicity in Obesity and Diabetes: Novartis Foundation Symposium 286

Example text

I am interested in plasma adiponectin levels in human patients and in mice overexpressing dominant negative mutant PPARγ. O’Rahilly: A few years ago we reported that the adiponectin levels were unusually low in our PPARγ dominant negative patients. Now that we have the whole group they don’t look so different from the other groups of non-PPARγ severe patients. The only ones that look totally different are the patients with insulin receptor mutations which have high adiponectin levels. All our patient groups are unusual.

4D). Consistent with these functional assessments, cDNA microarray analyses showed that fatty acid exposure in the context of low PGC1α activity (which is observed in obesity) resulted in the induction of classic PPARtargeted genes involved in lipid trafficking, glucose sparing and β -oxidation, but with little or no change in other downstream pathways that regulate respiratory capacity. In contrast, high PGC1α expression enabled the co-ordinated induction SKELETAL MUSCLE DYSFUNCTION 33 FIG. 4.

Lancet 1:785–789 Rosen ED, Sarraf P, Troy AE et al 1999 PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell Biol 4:611–617 Saha AK, Ruderman NB 2003 Malonyl-CoA and AMP-activated protein kinase: an expanding partnership. Mol Cell Biochem 253:65–70 Saltiel AR, Pessin JE 2002 Insulin signaling pathways in time and space. Trends Cell Biol 12:65–71 Shoelson SE, Lee J, Yuan M 2003 Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance.

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Fatty Acids and Lipotoxicity in Obesity and Diabetes: Novartis Foundation Symposium 286 by Novartis Foundation


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