By Kasirajan Ayyanathan
This vital booklet explores contemporary examine through specialists within the box referring to the function performed via genetic elements in human pathology. a number views creates a well-rounded photo, together with:
- host-pathogen interactions
- causal relationships among genes and the environment
- the results of environmental chemical compounds on gene expression
- DNA methylation
The publication additionally covers the research and offers versions for realizing the epigenetics-pathology connection.
This booklet is designed to be used through senior undergraduate and graduate scholars from numerous disciplines corresponding to basic, molecular, mobile biology, genetics, genomics, proteomics, and bioinformatics. it's going to additionally function a reference booklet for latest researchers and new investigators coming into this fairly unexplored box.
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Additional info for Epigenetics and Pathology: Exploring Connections Between Genetic Mechanisms and Disease Expression
Molecular aspects of defence priming. Trends in Plant Science 2011, 16: 524–531. 43. Boyko A, Kovalchuk I. Genetic and epigenetic effects of plant–pathogen interactions: an evolutionary perspective. Molecular Plant 2011, 4: 1014–1023. 44. Luna E, Bruce TJA, Roberts MR, Flors V, Ton J. Next-generation systemic acquired resistance. Plant Physiology 2012, 158: 844–853. 45. Relton CL, Davey Smith G. Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment.
In the case of the var family, the ability of the parasite to express only one of the 60 genes that encode for these proteins (called PfEMP1) is epigenetically regulated through histone modifications . In a recent study, Rovira-Graells et al.  have reported a more general association between these histone and chromatin marks and clonally variant expression, extending previous results on Plasmodium var genes to all but two of the 28 variantly expressed gene families. In addition, recent work has shown that the epigenetic state of the parasite is maintained during several rounds of cell division .
The fusion technique produces hybrid cells from differentiated somatic cells by nuclear reprogramming through the reactivation of embryo-specific genes, whose expressions are suppressed in somatic cells . In 2006, a four-gene set was introduced to reprogram somatic cells to a pluripotent state . Hybrid cells produced by fusion technique show a pluripotent state by expression of the pluripotent markers such as OCT4 . Moreover, a number of other genes such as Nanong, Sox2, Lin28, Klf4, c-Myc and AID have been correlated to the pluripotent state of a cell.
Epigenetics and Pathology: Exploring Connections Between Genetic Mechanisms and Disease Expression by Kasirajan Ayyanathan