Download PDF by James R. Brown: Comparative Genomics: Basic and Applied Research

By James R. Brown

ISBN-10: 0849392160

ISBN-13: 9780849392160

While genomic examine first got here at the scene, a lot of the biomedical learn neighborhood considered it as a restricted enterprise with constrained strength. We now understand that such an review used to be either hugely untimely and fantastically erroneous. within the final ten years, we’ve witnessed such awesome acceleration within the merger of easy and utilized genomic examine that, between different issues, genomic learn is now considered being intrinsic to present drug learn. via rigorous comparative research, the genomes of cold-blooded vertebrate, avian, and different mammalian species are offering a deeper figuring out of the human genome. additionally, genomic sequences, that are turning into to be had for a number of species have confirmed to be hugely correct to drug learn with reference to a couple of differently intractable stipulations.

Rather than supplying a finished quantity overlaying each point of comparative genomics, Comparative Genomics: simple and utilized learn embodies the varied pursuits of sought after researchers within the box. Compiling first hand descriptions in their pioneering paintings, the textual content specializes in commonalities and synergies around the wide box of comparative genomics. between its many issues it covers—

·         innovative advances in DNA-sequencing expertise

·         daring new methods to the association and research of huge phylogenetic info units

·         The influence of comparative genomics on our realizing of evolution

·         Efforts towards constructing novel antimicrobial medications, by utilizing bacterial pathogen genomes

Ultimately, destiny breakthroughs in comparative genomics will depend on the ongoing interplay and interdependency of utilized and simple examine. This seminal quantity demonstrates either the skill and the culmination of that cooperation, and in doing so defines and lays the basis for persisted development.

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Recently, the corporate landscape has changed dramatically, with giants in the genomics reagent and instrumentation market joining forces with or acquiring smaller technology developers. 12 More recently, Illumina Inc. 2,17 Presumably, more deals are in the pipeline, with an estimated US $1 billion market expected to grow even larger by 2015. 19 This milestone was accomplished using Sanger sequencing at a cost of more than US $300 million and 10 years of effort. 20 The winner must sequence at least 98%, with an error rate of 1 in 100,000 bases, at a cost of US $10,000 or less per genome.

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70. , Grindley, N. D. F. & Joyce, C. M. A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides. Proc. Natl. Acad. Sci. U. S. A. 85, 3402–3407 (1998). 71. , Henry, A. A. & Romesberg, F. E. Expanding the substrate repertoire of a DNA polymerase by directed evolution. J. Am. Chem. Soc. 126, 1748– 1754 (2004). 72. , Ruediger, S. & Liu, X. Labelled nucleotides. WO 2004/108493 A1, 2004. 73. Lewis, E. K. et al. Color-blind fluorescence detection for four-color DNA sequencing.

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Comparative Genomics: Basic and Applied Research by James R. Brown

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