Mohammad R. K. Mofrad, Roger D. Kamm's Cellular Mechanotransduction: Diverse Perspectives from PDF

By Mohammad R. K. Mofrad, Roger D. Kamm

ISBN-10: 0521895235

ISBN-13: 9780521895231

"Mechanotransduction" is the time period for the power, first defined through 19th-century anatomist Julius Wolff, of residing tissues to feel mechanical pressure and reply through tissue home improvement. extra lately, the scope of mechanotransduction has been multiplied to incorporate the feeling of tension, its translation right into a biochemical sign, and the series of organic responses it produces. This publication appears to be like at mechanotransduction in a extra constrained experience, targeting the method of pressure sensing and transducing a mechanical strength right into a cascade of biochemical indications. This rigidity has develop into more and more well-known as one of many fundamental and crucial components controlling organic capabilities, eventually affecting the functionality of the cells, tissues, and organs. a prime aim of this large e-book is additionally to assist outline the recent box of mechanomics, which makes an attempt to explain the full mechanical kingdom of a organic method.

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Additional resources for Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissues

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6 Endothelial Cell Biomechanics Of paramount importance to understanding mechanical sensing by the endothelium (or any organ) are the material properties of the cells comprising the tissue. The constitutive properties of the cell determine the spatial and temporal scales of force transmission and frictional dissipation at work in response to chemical or mechanical stimulation. A number of experimental and theoretical approaches have been employed to estimate viscoelastic moduli at a subcellular length scale and taking into account adhesive interactions with substrates of varying stiffness.

38(6): 786–800. Nerem, R. , Vascular fluid mechanics, the arterial wall, and atherosclerosis. J Biomech Eng, 1992. 114(3): 274–82. Schwartz, C. , Pathophysiology of the atherogenic process. Am J Cardiol, 1989. 64(13): 23G–30G. , Endothelial albumin permeability is shear dependent, time dependent, and reversible. Am J Physiol, 1991. 260(6 Pt 2): H1992–6. Friedman, M. H. and D. L. Fry, Arterial permeability dynamics and vascular disease. Atherosclerosis, 1993. 104(1–2): 189–94. Shieh, A. C. and K.

There are, however, several elements in these descriptions that require further clarification. First, ‘‘deformation’’ is a change of shape. In engineering terms it is the response to an applied force(s) that in the current context results from blood flow. This Endothelial Mechanotransduction 23 response may be a direct deformation of, for example, a cell surface feature(s) or of structures attached to the site(s) of direct deformation. However, change of position (displacement) of a structure in the cell may also occur passively and without deformation if the entire microvolume in which it is contained is displaced by the effects of adjacent, true deformation events.

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Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissues by Mohammad R. K. Mofrad, Roger D. Kamm


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