Download e-book for iPad: Cellular In Vitro Testing: Methods and Protocols by John Haycock, Arti Ahluwalia, J. Malcolm Wilkinson

By John Haycock, Arti Ahluwalia, J. Malcolm Wilkinson

ISBN-10: 9814364975

ISBN-13: 9789814364973

Growing cells in 2nd lower than static stipulations has lengthy been the premier of mobile tradition, regardless of this technique now not being consultant of the complicated in vivo environment. using animal types additionally has transparent moral and clinical boundaries, and more and more the 3Rs (replacement, refinement, relief) in terms of animal versions are being built-in into the modern day clinical practice.

Focusing on new 3D in vitro equipment now to be had to researchers, this ebook brings jointly examples of modern paintings being carried out across the world for bettering in vitro cellphone tradition tools, particularly using platforms for permitting mobile tradition below laminar circulation and using 3D scaffolds for supplying cells with a constitution which replicates the functionality of the extracellular matrix and inspiring interactions extra similar to an in vivo environment.

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John Haycock, Arti Ahluwalia, J. Malcolm Wilkinson's Cellular In Vitro Testing: Methods and Protocols PDF

Becoming cells in 2nd lower than static stipulations has lengthy been the choicest of cellphone tradition, regardless of this technique no longer being consultant of the advanced in vivo setting. using animal versions additionally has transparent moral and medical boundaries, and more and more the 3Rs (replacement, refinement, relief) with regards to animal versions are being built-in into the modern day medical perform.

Extra info for Cellular In Vitro Testing: Methods and Protocols

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Drug Disc Today: Dis Models 6, 137– 144. 42. , CaulFuty, M. (2009) A novel in vitro cell model of the human airway epithelium. 3R-Info-Bulletin 41(October 2009). 43. , Derouette, J. , Wiszniewski, L. (2008) MucilAir: a novel in vitro human 3D airway epithelium model for assessing the potential hazard of nanoparticles and chemical compounds. Toxicol Lett 180, S233. 44. Maier, M. S. V. (2011) Setting occupational exposure limits for unstudied pharmaceutical intermediates using an in vitro parallelogram approach.

Swartz, M. A. (2006) Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7, 211–224. 14. , Basketter, D. , Gerberick, G. , Lepoittevin, J. , Meade, B. , Verheyen, G. , Zuang, V. (2005) Dendritic cells as a tool for the predictive identification of skin sensitisation hazard Report and recommendations of ECVAM Workshop 51. Altern Lab Anim 33, 47–62. 15. Santegoets, S. , van den Eertwegh, A. , van de Loosdrecht, A. , Scheper, R. , de Gruijl, T. D. (2008) Human dendritic cell line models for DC differentiation and clinical DC vaccination studies.

Ahluwalia, A. (2010) A low shear stress modular bioreactor for connected cell culture under high flow rates. Biotechnol Bioeng 106(1), 127–137. 3. Weibel, E. , Bacigalupe, L. , Hoppeler, H. (2004) Allometric scaling of maximal metabolic rate in mammals: muscle aerobic capacity as determinant factor. Resp Physiol Neurobiol 140, 115– 132. 4. gov. 5. Dawson, T. H. (2003) Scaling law for capillary vessels of mammals at rest and in exercise. Proc Biol Sci 270(1516), 755–763. 6. , Shibata, M. (1987) Optimum capillary number for oxygen delivery to tissue in man.

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Cellular In Vitro Testing: Methods and Protocols by John Haycock, Arti Ahluwalia, J. Malcolm Wilkinson


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