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Members of the kinesin superfamily and cytoplasmic dynein are the key motors in the axonal traffic machinery. Motor proteins from the myosin superfamily also play some role in axonal transport; however this movement is thought to be short range, such as the dispersal of cargo to the cell periphery. In axons, microtubules are oriented with plus ends (fast growing) directed toward the periphery and minus ends (slow growing) toward the cell body. Conventional kinesin is an anterograde axonal transporter that supplies new material to the axon and the presynaptic terminal.

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Sci. U S A 98, 2399–2406. , Haberlein, H. (2003). Lateral mobility and specific binding to GABA(A) receptors on hippocampal neurons monitored by fluorescence correlation spectroscopy. Biochemistry 42, 1667–1672. P. (2001). The influence of macromolecular crowding and macromolecular confinement on biochemical reactions in physiological media. J. Biol. Chem. 276, 10577–10580. , Gall, K. (2002). Fluorescence intensity and lifetime distribution analysis: Toward higher accuracy in fluorescence fluctuation spectroscopy.

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Cellular Biology - A Short Course by S. Bolsover, et al.,


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