By K. Christopher Garcia (Eds.)
Cellphone floor Receptors comprises an in depth dialogue of telephone floor receptors in eleven chapters by way of specialists of their box. As cellphone floor receptors are serious about virtually each point of signaling in the course of the physique, the subject has been of excessive curiosity locally lately. chosen Contents:-Structures of Axon assistance Molecules and Their Neuronal Receptors-Shared Cytokine Signaling Receptor-NKG2D and comparable Immunoreceptors-Inonotropic Glutamat Receptor attractiveness and Activation-Chemotaxis Receptors and Signaling
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Instead, ligand-binding affinity appears to be regulated primarily by conformational changes in loops of the I-like domain and possibly also in the -propeller domain. G. , receptors coupled to G proteins or tyrosine kinases) impinge on integrin cytoplasmic domains and enhance the affinity of the extracellular headpiece for ligand. Recently the basis for bidirectional signal transmission across the membrane by integrins has been explained. The integrin and cytoplasmic tails associate with each other and constrain the integrin in its inactive form.
Dramatic rearrangements occur in the orientation of these domains during integrin activation (Fig. , 2002). In this review we will focus primarily on the integrin headpiece, where ligands bind. However, it should be emphasized that in the bent conformation, extensive interfaces totaling over 4000 A˚ 2 of solvent accessible surface are buried between the headpiece and tailpiece and between the tailpiece and tailpiece. These interfaces stabilize the bent conformation, and are important in regulating 32 SPRINGER AND WANG Fig.
References .. . . . . . . . . . . . .. . . . . . . . . . . . .. . . . . . . . . . . . .. . . 30 31 31 32 33 33 35 37 37 41 42 43 44 47 47 51 51 53 54 56 57 Abstract Integrins are a structurally elaborate family of adhesion molecules that transmit signals bidirectionally across the plasma membrane by undergoing large-scale structural rearrangements. By regulating cell-cell and cell-matrix contacts, integrins participate in a wide-range of biological interactions including development, tissue repair, angiogenesis, inflammation and hemostasis.
Cell Surface Receptors by K. Christopher Garcia (Eds.)