By Jyrki Heino
Univ. of Turku, Finland. presents an summary of mobilephone invasion. issues comprise details at the mobile matrix, phone floor integrins, matrix metalloproteinases and proteinases, and the interaction among protein households.
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Extra info for Cell Invasion (Medical Intelligence Unit)
Integrins and other cell adhesion molecules. FASEB J 1990; 4:2868-2880. 27. Larson RS, Springer TA. Structure and function of leukocyte integrins. Immunol Rev 1990; 114:181-217. 28. Hemler ME, Elices MJ, Parker C, Takada Y. Structure of the integrin VLA-4 and its cell-cell and cell-matrix adhesion functions. Immunol Rev 1990; 114:45-65. 29. Springer TA. Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain. Proc Natl Acad Sci USA 1997; 94:65-72.
63 These studies emphasize the importance of α2β1 integrin in normal mammary epithelium. 65 Thus, it is possible that during malignant transformation, changes in the expression of a key integrin lead to altered expression of other integrins. Links between the integrins and other important factors contributing to the progression of breast tumors have also been traced. It has been postulated that hepatocyte growth factor/ scatter factor (HGF/SF) is able to increase the adhesion of breast cancer cells to laminins 1 and 5, fibronectin, and vitronectin through a PI3 kinase-related mechanism.
Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes. J Biol Chem 1998; 273:20383-20389. 18. Lehnert K, Ni J, Leung E, Gough SM, Weaver A et al. Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11). Genomics 1999; 60:179-187 19. Velling T, Kusche-Gullberg M, Sejersen T, Gullberg D. cDNA cloning and chromosomal localization of human alpha(11) integrin.
Cell Invasion (Medical Intelligence Unit) by Jyrki Heino