By Clifford P Stanners
Considers the new explosion of data concerning the carcinoembryonic antigen (CEA) relatives, which resulted from the molecular cloning of loved one genes in 1986.
Results indicating CEA relations upregulated in melanoma may have an instrumental function in malignant transformation and metastasis, whereas those who are downregulated can have tumor suppressive capabilities are thought of. reports, fresh effects, hypotheses, and scientific functions relating to a gene kinfolk that, from its common alterations in expression in tumors at many websites, could be considered as a "major participant" in human melanoma also are mentioned. the traditional capabilities equivalent to epithelial and hematopoietic adhesion and signalling molecules are explored, and the potentially detailed function of this kinfolk in evolution is brought.
This quantity may be of curiosity to researchers within the fields of intercellular adhesion, evolution, and molecular reputation, in addition to clinicians attracted to the hot wisdom concerning a tumor marker as a rule utilised within the hospital, and corporations wishing to use this cancer-related family members for novel advertisement purposes within the biomedical sphere.
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Extra info for Cell adhesion and communication mediated by the CEA family : basic and clinical perspectives
1990) Specificity of intercellular adhesion mediated by various members of the immunoglobulin supergene family. , 1, 209–215. P. and Fuks, A. (1993b) Specificity of anti-carcinoembryonic antigen monoclonal antibodies and their effects on CEA-mediated adhesion. , 53, 3817– 3822. , Friedrich, R. and von Kleist, S. (1987) Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure. Proc. Natl. Acad. Sci. USA, 84, 2960–2964.
Identification of regulatory elements and multiple nuclear factors. J. Biol. , 270, 3602–3610. R. and Beauchemin, N. (1995) Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas. Eur. , 223, 529–541. J. E. HAMMARSTRÖM ET AL. glycosylphosphatidylinositol moiety: Identification of the ethanolamine linkage site. Proc. Natl. Acad. Sci. USA, 85, 4648– 4652. E. J. (1988) Molecular cloning of a cDNA coding biliary glycoprotein I: Primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen.
In summary, three different patterns of cellular expression can be recognized: (1) selective epithelial (CEA and CGM2), (2) granulocytic (CGM6, CGM1 and CGM7) and (3) broad (BGP and NCA50/90). Although not much is known about the remaining four molecules, CGM2 seems to have a similar distribution to that of CEA, being expressed in certain epithelial cells and not in granulocytes. CGM6, CGM1 and CGM7, on the other hand, are expressed in granulocytes but probably not in epithelial cells. Human tumor tissues Table 2 summarizes the information on the expression of CEA subfamily members in epithelial and other types of tumors.
Cell adhesion and communication mediated by the CEA family : basic and clinical perspectives by Clifford P Stanners