Download PDF by Connie M. Weaver, Robert P. Heaney: Calcium in Human Health

By Connie M. Weaver, Robert P. Heaney

ISBN-10: 1588294528

ISBN-13: 9781588294524

This complete overview of the nation of our wisdom bearing on calcium not just demonstrates its value to human well-being, but in addition defines its many complicated roles. The authors summarize the newest easy clinical info at the mobile and metabolic services of calcium, explaining the top suggestions for competently measuring its bioavailability, absorption, and kinetics, and displaying that calcium deficiency is an enormous challenge whereas calcium extra an extraordinary one. additionally they learn the complicated law of calcium absorption, distribution, and excretion, in addition to the a number of interactions of diet/lifestyle, and actual job in calcium homeostasis. Their dialogue of the explicit roles of calcium in various medical disorders-osteoporosis, oral healthiness, weight problems, reproductive issues, and the metabolic syndrome-provides new insights and increases new questions. The complicated alterations in calcium and phosphate law that happen in renal ailment and the capability position of calcium in high blood pressure and vascular affliction also are addressed.

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The store-operated Ca2+ channels are ubiquitous, having been demonstrated in many different cell types. The electrophysiological characteristics of these channels differ from cell to cell, giving rise to the demonstration of different types of this channel. Although the molecular identity of the channel has not been established unequivocally, TRP proteins have been implicated (43). Presenilin-1 is one of the genes implicated in the etiology of early-onset autosomaldominant or familial-onset Alzheimer’s disease (14).

Abnormal intracellular Ca2+ homeostasis and disease. Cell Calcium 2000;28:1–21. 32. McFadzean IM, Gibson A. The developing relationship between receptor-operated and store-operated calcium channels in smooth muscle. Br J Pharmacol 2002;135:1–13. 33. Tsunoda Y. Receptor-operated calcium influx mediated by protein tyrosine kinase pathways. J Recept Signal Transduct Res 1998;18:281–310. 34. Oonuma H, Nakajima T, Nagata T, et al. Endothelin-1 is a potent activator of nonselective cation currents in human bronchial smooth muscle cells.

Cir Res 1992;71:1242–1253. 27. Giles TD. Hypertension and pathologic cardiovascular remodeling: a potential therapeutic role for Ttype calcium antagonists. Clin Ther 1997;19:27–38. 28. Ertel SI, Ertel EA, Clozel JP. T-type Ca2+ channels and pharmacological blockade: potential pathophysiological relevance. Cardiovasc Drugs Ther 1997;11:723–739. 29. Snutch TP, Sutton KG, Zamponi GW. Voltage-dependent calcium channels- beyond dihydropyridine antagonists. Curr Opin Pharmacol 2001;1:11–16. 30. Dryer SE, Lhuillier L, Cameron JS, Martin-Caraballo M.

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Calcium in Human Health by Connie M. Weaver, Robert P. Heaney

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