Download e-book for iPad: Bone Cancer: Progression and Therapeutic Approaches, 1st by Dominique Heymann

By Dominique Heymann

ISBN-10: 012374895X

ISBN-13: 9780123748959

The epidemiological and scientific significance of bone metastasis has lengthy been famous, however the previous decade has visible an explosion within the fields of bone biology and bone melanoma study. this time period has been marked through a few key discoveries that experience resulted in the outlet up of completely new parts for research in addition to new cures which mix surgical procedure and organic healing approaches.Bone is a typical website of melanoma metastases - melanoma cells normally advance in bone and unfold to different organ platforms in the course of the bloodstream. for instance, the prevalence of bone metastases in breast and prostate cancers is 70%, while it's only 30 to forty% in metastatic lung melanoma. In scientific phrases, bone metastases have large unwanted effects on a patient's caliber of lifestyles and are a chief reason for sufferer mortality. Given the worldwide incidence of breast and prostate cancers, wisdom of bone biology has develop into crucial for the clinical and melanoma examine groups. This booklet offers, multi functional source, the latest information on bone melanoma improvement (cellular and molecular mechanisms), genomic and proteomic analyses, medical analyses (histopathology, imaging, soreness monitoring), in addition to new healing techniques and medical trials for basic bone tumors and bone metastases. function offers a accomplished, translational resource for all points of bone melanoma in a single reference paintings Bone melanoma specialists (from all components of study and perform) take readers from the bench study (cellular and molecular mechanism), via genomic and proteomic research, all of the strategy to medical research (histopathology and imaging) and new healing ways. transparent presentation through bone biologists of the mobile and molecular mechanisms underlying bone tumors and bone melanoma metastasis in addition to the genomic and proteomic assays utilized in detecting melanoma inside of given organ structures transparent presentation via oncologists and radiologists of ways histopathology, imaging, and discomfort tracking may end up in new healing techniques gain Saves researchers and clinicians time in speedy getting access to the very most up-to-date info on a large diversity of bone melanoma concerns, in preference to looking through hundreds of thousands of magazine articles. offers a standard language for melanoma researchers, bone biologists, oncologists, and radiologists to debate bone tumors and the way bone melanoma metastases impacts each one significant organ procedure right analysis (and for this reason right therapy) of melanoma is determined by a robust knowing of the molecular foundation for the sickness - either oncologists and radiologists will gain Bone biologists will achieve perception into how medical observations and practices can feed again into the learn cycle and may, for this reason, manage to improve extra detailed genomic and proteomic assays

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Additional info for Bone Cancer: Progression and Therapeutic Approaches, 1st Edition

Sample text

Mechanisms of Multiple Myeloma-Induced Bone Resorption The importance of osteoclasts and bone resorption in MM was demonstrated in the 5T2MM mouse model [314] and in the SCID-hu-MM model, where fragments of human long bones inoculated with MM cells are grafted in SCID mice [315], using bisphosphonates which inhibit osteoclast activity. Zoledronic acid and pamidronate successfully decreased bone resorption induced by MM cells as well as the tumor burden and increased mouse survival. However, bisphosphonate effects on myeloma cells in bones could be attributed to direct anti-tumor properties that have been shown in vitro on MM cells [316–318].

Waltregny, A. Bellahcene & X. , Increased expression of bone sialoprotein in bone metastases compared with visceral metastases in human breast and prostate cancers, J Bone Miner Res 15 (2000) 834–843. 193. Y. Ogata, N. Niisato & S. , Transforming growth factor-beta 1 regulation of bone sialoprotein gene transcription: identification of a TGF-beta activation element in the rat BSP gene promoter, J Cell Biochem 65 (1997) 501–512. 194. S. M. J. , Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer, Cancer Res 66 (2006) 6327–6335.

117. A. A. Mousa & M. , Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral GpIIb/IIIa antagonist XV454, Thromb Haemost 90 (2003) 549–554. 118. J. Bakewell, P. Nestor & S. , Platelet and osteoclast beta3 integrins are critical for bone metastasis, Proc Natl Acad Sci USA 100 (2003) 14205–14210. 119. A. M. Serre & S. , Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer, J Clin Invest 114 (2004) 1714–1725.

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Bone Cancer: Progression and Therapeutic Approaches, 1st Edition by Dominique Heymann


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