Bone Cancer: Progression and Therapeutic Approaches by Dominique Heymann PDF

By Dominique Heymann

ISBN-10: 012374895X

ISBN-13: 9780123748959

The epidemiological and medical value of bone metastasis has lengthy been well-known, however the prior decade has noticeable an explosion within the fields of bone biology and bone melanoma examine. this time period has been marked by means of a couple of key discoveries that experience ended in the outlet up of solely new parts for research in addition to new cures which mix surgical procedure and organic healing methods. Bone is a standard web site of melanoma metastases - melanoma cells ordinarily boost in bone and unfold to different organ structures throughout the bloodstream. for instance, the prevalence of bone metastases in breast and prostate cancers is 70%, while it is just 30 to forty% in metastatic lung melanoma. In medical phrases, bone metastases have monstrous unwanted effects on a patient's caliber of existence and are a major explanation for sufferer mortality. Given the worldwide occurrence of breast and prostate cancers, wisdom of bone biology has develop into crucial for the scientific and melanoma learn groups. This e-book offers, multi function source, the latest facts on bone melanoma improvement (cellular and molecular mechanisms), genomic and proteomic analyses, scientific analyses (histopathology, imaging, soreness monitoring), in addition to new healing methods and medical trials for basic bone tumors and bone metastases.


  • Presents a finished, translational resource for all points of bone melanoma in a single reference work
  • Bone melanoma specialists (from all components of study and perform) take readers from the bench study (cellular and molecular mechanism), via genomic and proteomic research, all of the strategy to scientific research (histopathology and imaging) and new healing methods.
  • Clear presentation by way of bone biologists of the mobile and molecular mechanisms underlying bone tumors and bone melanoma metastasis in addition to the genomic and proteomic assays utilized in detecting melanoma inside given organ systems
  • Clear presentation by means of oncologists and radiologists of the way histopathology, imaging, and ache tracking may end up in new healing approaches
  • Benefit

  • Saves researchers and clinicians time in fast gaining access to the very most recent information on a extensive diversity of bone melanoma matters, in place of looking through millions of magazine articles.
  • Provides a typical language for melanoma researchers, bone biologists, oncologists, and radiologists to debate bone tumors and the way bone melanoma metastases impacts each one significant organ system
  • Correct prognosis (and hence right remedy) of melanoma relies on a robust knowing of the molecular foundation for the sickness - either oncologists and radiologists will profit
  • Bone biologists will achieve perception into how medical observations and practices can feed again into the learn cycle and may, for that reason, manage to boost extra certain genomic and proteomic assays

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Additional resources for Bone Cancer: Progression and Therapeutic Approaches

Sample text

Lacroix, B. J. , Production and regulation of interleukin-11 by breast cancer cells, Cancer Lett 127 (1998) 29–35. 123. B. A. Berry & A. , COX-2 induces IL11 production in human breast cancer cells, J Surg Res 131 (2006) 267–275. 124. H. Morgan, A. A. Hill, Breast cancer cells induce osteoclast formation by stimulating host IL-11 production and downregulating granulocyte/macrophage colonystimulating factor, Int J Cancer 109 (2004) 653–660. 125. E. Romas, N. Udagawa & H. , The role of gp130mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures, J Exp Med 183 (1996) 2581–2591.

MIP-1 neutralizing antibodies blocked osteoclast formation in bone marrow cultures treated with human myeloma bone marrow plasma [327] and reduced osteolysis in an in vivo mouse myeloma model [328]. MM cells induce bone destruction via cell-cell interactions with BMSCs through cell adhesion molecules. The integrin 41, also named very late antigen-4 (VLA-4), is expressed at the surface of myeloma cells [329,330] and interacts with the vascular adhesion molecule-1 (VCAM-1) constitutively expressed on BMSCs [331,332].

S1, in mice [299]. The IGF-IR is expressed by a wide variety of MM cell lines tested and detected in fresh samples from MM patients [300]. Inhibition of IGF-IR can also abrogate IL-6-induced proliferation in some MM cell lines suggesting a pivotal role for IGF-I [300]. The cell responses to IGF-I and IL-6 are not inhibited by antibodies neutralizing gp130 and IGFIR or IGF-I, respectively, suggesting that they are mediated through independent pathways, and that combination of IGF-I and IL-6 can induce an additive increase of MM cell survival [301].

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Bone Cancer: Progression and Therapeutic Approaches by Dominique Heymann

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