By John N. Abelson, Melvin I. Simon, Sidney Fleischer, Becca Fleischer
The delivery volumes of the Biomembranes sequence have been initiated with Volumes a hundred twenty five and 126 of tools in Enzymology, which lined shipping in micro organism, Mitochondria, and Chloroplasts. Volumes 156 and 157 endured the subject matter with ATP-Driven Pumps and comparable shipping. mobile and Subcellular shipping: Eukaryotic (Nonepithelial) Cells was once the subject of Volumes 173 and 174. The subject matter of this quantity, in addition to of quantity 192, is mobile and Subcellular shipping: Epithelial Cells
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Additional resources for Biomembranes Part V: Cellular and Subcellular Transport: Epithelial Cells
For k = 0 (ionophore highly selective for the  PARACELLULAR SHUNT CONDUCTANCE IN EPITHELIA 27 actively transported ion) Eq. (B8) reduces to dGT/dI~ = R-a/[Ea~(R-a + RbO -- E-aR~ + E~R-a] (B10) This expression is independent of x and hence indicates that the relationship between GT and I~ is linear. The same holds also for k = 1 (nonselective ionophore), in which case Eq. ,R-a + E~2R,,, + E~ (Ral + R,a)] (BI 1) The situation is different, however, if we consider the error AG x in determining the shunt conductance G~ by linear extrapolation.
Kottra and E. Fr0mter, Pfluegers Arch. ,102, 409 (1984). 4s C. Clansen, S. A. Lewis, and J. M. Diamond, Biophys. J. 26, 291 (1979). 49 G. Kottra and E. FrOmter, Pfluegers Arch. ,102, 421 (1984). 5o C. Clansen, P. S. Reinach, and D. C. Marcus, J. Membr. Biol. 91, 213 (1986). 51j. R. Pappcnheimer, J. Membr. Biol. 100, 137 (1987).  PARACELLULAR SHUNT CONDUCTANCE IN EPITHELIA 19 quency-dependent voltage divider ratio? 7 In experiments on Necturus gallbladder such measurements have clearly indicated that the distributed model (Fig.
BI. Model of the epi~efiura wi~ two distinct apical permeation pathways. For details see text. Case A corresponds to k = 0 (the ionophore transfers only ion 1, but R~ does not change). Case B corresponds to 0 < k < 1 (the ionophore also has a small selectivity for ion 2; however, Ral and Ra2 change differently). ~ are lowered by the same factor x). We now consider the general case and derive GT and I~ for the equivalent circuit of Fig. B 1. h --- xRal + [1 + k(x - 1)]R~ + G,h (B1) x[1 + k(x - 1)]R,,R,a + Rb~(xR,, + [1 + k(x - 1)]R~2) where Gel is the conductance of the transcellular permeation pathway.
Biomembranes Part V: Cellular and Subcellular Transport: Epithelial Cells by John N. Abelson, Melvin I. Simon, Sidney Fleischer, Becca Fleischer