New PDF release: Basic Endocrinology for Students of Pharmacy and Allied

By Andrzej Bartke, Andrew Constanti

ISBN-10: 020316413X

ISBN-13: 9780203164136

ISBN-10: 0203301730

ISBN-13: 9780203301739

ISBN-10: 9057022516

ISBN-13: 9789057022517

This textbook has been written essentially for undergraduate scholars of pharmacy, toxicology, and drugs who require a concise reference e-book on easy endocrine functionality and disorder.

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Sample text

Principal metabolic actions of cortisol. Protein and fat breakdown are promoted with a resultant release of amino acids and glycerol substrates, utilized by the liver for glucose and glycogen synthesis. The insulin-sensitive uptake of glucose by fat and muscle cells is also inhibited. ANTI-INFLAMMATORY EFFECT The mechanisms underlying the anti-inflammatory actions of glucocorticoids are varied and complex, as are the sequence of reactions involved in the inflammatory response itself. The latter may be regarded as a primary defensive reaction of tissues to trauma, harmful invading organisms or chemical substances and other antigenic agents, and is intended to protect the host tissue from further damage.

3. 4. 5. 6. 3. Pathways for synthesis of adrenocortical steroids from cholestrol: (numbers in brackets indicate intermediate stynthesis steps omitted for clarity). Note that the conversion of corticosterone to aldosterone occurs only within the zona glomerulosa which lacks 17α-hydroxylase enzyme activity, and is thus unable to produce cortisol or androgens; also the enzyme aromatase (oestrogen synthetase) catalyses the conversion of testosterone to oestradiol, as well as the direct conversion of androstenedione to oestrone.

27–44 • Guyton AC, Hall JE. (1996). The pituitary hormones and their control by the hypothalamus. In Textbook of Medical Physiology, 9th ed. WB Saunders Company, USA, pp. 933–944 • Hassan T. (1985). The pituitary gland. In A Guide to Medical Endocrinology, Macmillan Publishers Ltd, pp. 22–43 • Hedge GA, Colby HD, Goodman RL. (1987). The brain-pituitary interface. In Clinical Endocrine Physiology, WB Saunders Co, Philadelphia, Chapters 3–5, pp. 53–98 • Junqueira LC, Carneiro J, Long JA. (1986). Pituitary & Hypothalamus.

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Basic Endocrinology for Students of Pharmacy and Allied Health Sciences by Andrzej Bartke, Andrew Constanti

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