By Lori A. Erickson
Atlas of Endocrine Pathology presents a accomplished compendium of photomicrographs of universal and unusual entities in endocrine pathology. the amount comprises histologic beneficial properties of ordinary positive factors, reactive stipulations, hyperplasia and tumors. the main precious diagnostic good points are illustrated to supply path and clues to the analysis of endocrine tumors. moreover, photomicrographs spotlight the main pertinent diagnostic gains in not easy diagnoses in endocrine pathology.
Authored by means of a nationally and the world over famous pathologist, Atlas of Endocrine Pathology is a crucial studying instrument for these changing into conversant in the various entities encountered in endocrine pathology and a precious reference for practising pathologists confronted with difficult diagnoses in endocrine pathology.
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Occasional oncocytic cells may be seen in Graves disease, particularly with preoperative treatment, but the oncocytic change is very focal compared with the extensive oncocytic change in Hashimoto thyroiditis Fig. 8 Graves disease (diffuse hyperplasia). This thyroid involved by Graves disease shows some scalloping of colloid, and the cells are still fairly columnar, compatible with hyperthyroidism. However, the increased colloid and decreased vascularity are compatible with the thyroid having been treated preoperatively with iodine 24 3 Graves Disease (Diffuse Hyperplasia) References Fig.
Endocr Pathol. 2009;20(4):197–203. 22. Mitchell JD, Kirkham N, Machin D. Focal lymphocytic thyroiditis in Southampton. J Pathol. 1984;144(4):269–73. 3 Graves Disease (Diffuse Hyperplasia) Graves disease, an autoimmune disorder, is the most common cause of hyperthyroidism. Graves disease is associated with antibodies against the thyrotropin receptor that stimulate the receptor and promote synthesis and secretion of thyroglobulin and follicular cell proliferation. Patients present with goiter and symptoms of hyperthyroidism, including anxiety, tachycardia, palpitations, tremor, heat sensitivity, and weight loss, and may develop ophthalmopathy and dermopathy.
12. Volpe R. Subacute thyroiditis. Prog Clin Biol Res. 1981;74:115–34. 13. Volpe R. The pathology of thyroiditis. Hum Pathol. 1978; 9(4):429–38. 14. Few J, et al. Riedel’s thyroiditis: treatment with tamoxifen. Surgery. 1996;120(6):993–8; discussion 998–9. 15. Heufelder AE, Hay ID. Further evidence for autoimmune mechanisms in the pathogenesis of Riedel’s invasive fibrous thyroiditis. J Intern Med. 1995;238(1):85–6. 16. Dahlgren M, et al. Riedel’s thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum.
Atlas of Endocrine Pathology by Lori A. Erickson