By Joseph V. Rodricks and Robert G. Tardiff (Eds.)
content material: Conceptual foundation for threat overview / Joseph V. Rodricks and Robert G. Tardiff --
Use of toxicity try facts within the estimation of hazards to human healthiness / Norton Nelson --
Interspecies extrapolation / Daniel B. Menzel and Elaine D. Smolko --
simple recommendations of the dose-response courting / Robert Snyder --
excessive- to low-dose extrapolation in animals / Charles C. Brown --
felony concerns in probability evaluation below federal regulatory statutes / Peter Barton Hutt --
Inter-risk comparisons / E.A.C. Crouch and Richard Wilson --
Uncertainty and quantitative evaluate in possibility administration / M. Granger Morgan --
Use of probability evaluate and security overview / Virgil O. Wodicka --
the necessity for probability review of chemical substances in company choice making / Fred Hoerger --
Chemical views on regulatory effect research / René D. Zentner.
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Extra resources for Assessment and Management of Chemical Risks
The dose producing h a l f of the maximal response i s c a l l e d the ED50, i . e . the dose g i v i n g 50% of the maximal response. An example of the p r a c t i c a l a p p l i c a t i o n of t h i s technique i s taken from a paper by Bicker ton (11) who i n v e s t i g a t e d the e f f e c t s of catecholamines on the i s o l a t e d c a t spleen. The spleen c o n t r a c t ( e p i ) or norepinepherin be measured on a s t r a i n gauge and increases as the c o n c e n t r a t i o n of catecholamine i n the system i s r a i s e d .
4. SNYDFR 39 Dose-Response Relationship F i n a l l y problems of the dose-re»punse r e l a t i o n s h i p low dose exposure w i l l be explored. r e l a t i v e to Bioassay Systems The s i n g l e most important e n t i t y i n the study of the doseresponse relationship i s the bioassay system i n which the chemical w i l l be s t u d i e d . Since the most e s s e n t i a l f e a t u r e of the r e s u l t s w i l l be the q u a n t i t a t i v e data which are d e r i v e d , the r u l e s governing the accuracy and p r e c i s i o n of the assay should approach as n e a r l y as p o s s i b l e those achieved i n measurements i n chemical systems.
The number of standard d e v i a t i o n s on e i t h e r side of the median response, has been devised and can be used as a means of expressing the response. To avoid the use of p o s i t i v e and negative numbers, and r e c o g n i z i n g that i t i s l i k e l y that data w i l l not f r e q u e n t l y be c o l l e c t e d which l i e s more than a few standard d e v i a t i o n s from the mean, a convention has been adopted c a l l e d the p r o b i t . The number 5 i s added to the NED to y i e l d p o s i t i v e numbers and i n d i c a t e s the number of standard d e v i a t i o n s from the mean that the response i s found.
Assessment and Management of Chemical Risks by Joseph V. Rodricks and Robert G. Tardiff (Eds.)