Download PDF by Weihong Tan, Xiaohong Fang: Aptamers Selected by Cell-SELEX for Theranostics

By Weihong Tan, Xiaohong Fang

ISBN-10: 3662462257

ISBN-13: 9783662462256

ISBN-10: 3662462265

ISBN-13: 9783662462263

This edited quantity describes cell-SELEX because the primary device used to generate aptamer molecules for a variety of purposes in molecular drugs, bioanalysis and chemical biology. simply built-in into the typical heterogeneous mobilephone matrix, aptamers should be successfully utilized in theranostics, bioanalysis, setting detection and biomedical reports. The e-book gathers reports that replicate the newest advances within the box of aptamers, and is composed in fourteen chapters demonstrating crucial examples of those aptamers and aptamer-nanomaterial assemblies, looking on the kinds of purposes and organic platforms. it is usually a separate bankruptcy at the usage of aptamers in actual clinics and what is going to be required to accomplish this important aim. The ebook should be either attractive and priceless to a large viewers, together with biologists, bioscientists, and clinicians whose pursuits variety from chemistry and biomedical engineering to phone and molecular biology and biotechnology.

Weihong Tan is a unusual Professor of Chemistry and Biomedical Engineering at Hunan collage, China and likewise a school of Florida exotic Professor and V.T. and Louis Jackson Professor of Chemistry on the college of Florida, USA.

Xiaohong Fang is a Professor on the Institute of Chemistry, chinese language Academy of Sciences, China.

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Extra info for Aptamers Selected by Cell-SELEX for Theranostics

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1021/cr300468w 2. Ellington AD, Szostak JW (1990) In vitro selection of RNA molecules that bind specific ligands. Nature 346(6287):818–822. 1038/346818a0 3. Tuerk C, Gold L (1990) Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249(4968):505–510 4. Lee JF, Stovall GM, Ellington AD (2006) Aptamer therapeutics advance. Curr Opin Chem Biol 10(3):282–289. 015 5. Morris KN, Jensen KB, Julin CM, Weil M, Gold L (1998) High affinity ligands from in vitro selection: complex targets.

Legiewicz M, Yarus M (2005) A more complex isoleucine aptamer with a cognate triplet. J Biol Chem 280(20):19815–19822. M502329200 34. Manimala JC, Wiskur SL, Ellington AD, Anslyn EV (2004) Tuning the specificity of a synthetic receptor using a selected nucleic acid receptor. J Am Chem Soc 126(50):16515– 16519. 1021/ja0478476 35. Sayer NM, Cubin M, Rhie A, Bullock M, Tahiri-Alaoui A, James W (2004) Structural determinants of conformationally selective, prion-binding aptamers. J Biol Chem 279 (13):13102–13109.

References 1. Tan W, Donovan MJ, Jiang J (2013) Aptamers from cell-based selection for bioanalytical applications. Chem Rev 113(4):2842–2862. 1021/cr300468w 2. Ellington AD, Szostak JW (1990) In vitro selection of RNA molecules that bind specific ligands. Nature 346(6287):818–822. 1038/346818a0 3. Tuerk C, Gold L (1990) Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249(4968):505–510 4. Lee JF, Stovall GM, Ellington AD (2006) Aptamer therapeutics advance.

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Aptamers Selected by Cell-SELEX for Theranostics by Weihong Tan, Xiaohong Fang


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