Ronald Wetzel, Indu Kheterpal's Amyloid, Prions, and Other Protein Aggregates, Part C PDF

By Ronald Wetzel, Indu Kheterpal

ISBN-10: 0121828182

ISBN-13: 9780121828189

The facility of polypeptides to shape however folded, polymeric buildings resembling amyloids and comparable aggregates is being more and more famous as a huge new frontier in protein examine. This new quantity of tools in Enzymology besides half B (volume 412) on Amyloid, Prions and different Protein Aggregates proceed within the culture of the 1st quantity (309) in containing distinctive protocols and methodological insights, supplied via leaders within the box, into the most recent equipment for investigating the buildings, mechanisms of formation, and organic actions of this significant type of protein assemblies.

* provides distinct protocols
* contains troubleshooting tips
* offers insurance on structural biology, computational equipment, and biology

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335, 81–90. , Benedek, G. , and Teplow, D. B. (1999). Monitoring protein assembly using quasielastic light scattering spectroscopy. Methods Enzymol. 309, 429–459. , Chung, D. , Benedek, G. , Kirschner, D. , and Teplow, D. B. (1996). On the nucleation and growth of amyloid ‐protein fibrils: Detection of nuclei and quantitation of rate constants. Proc. Natl. Acad. Sci. USA 93, 1125–1129. , Teplow, D. , and Benedek, G. B. (2005). Quasielastic light scattering for protein assembly studies. In ‘‘Amyloid Proteins: Methods and Protocols’’ (E.

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Vaccination with soluble A oligomers generates toxicity‐neutralizing antibodies. J. Neurochem. 79, 595– 605. Lazo, N. , Maji, S. , Fradinger, E. , and Teplow, D. B. (2005). The amyloid ‐protein. In ‘‘Amyloid Proteins—The Beta Sheet Conformation and Disease’’ (J. C. ), pp. 385–492. Wiley‐VCH, Weinheim. , III. (1995). Soluble multimeric Alzheimer (1‐40) pre‐amyloid complexes in dilute solution. Neurobiol. Aging 16, 755–764. , III. (2004). Alzheimer’s ‐peptide oligomer formation at physiologic concentrations.

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Amyloid, Prions, and Other Protein Aggregates, Part C by Ronald Wetzel, Indu Kheterpal

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