By Etelka Farkas, Maxim Ryadnov, Jonathan Heddle, Ferenc Hudecz, Shuguang Zhang, Luc Brunsveld, Jason Crain
Written for researchers, teachers and pros, those papers symbolize an crucial reference resource at the newest developments and findings within the box of proteins, amino acids and peptides. content material: Preface; Amino acid and petide bioconjugates; Self-assembling peptide fabrics; steel complexes of amino acids and peptides; version platforms for folding and teriary contacts in peptides: A standpoint from the actual sciences; Protein nanotubes, channels and cages; Prescriptive peptide layout; concentrating on alpha-helix dependent protein interactions - nuclear receptors as a case research summary: Written for researchers, lecturers and pros, those papers signify an fundamental reference resource at the most up-to-date tendencies and findings within the box of proteins, amino acids and peptides
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Extra resources for Amino Acids, Peptides and Proteins Vol. 37
Zeglis, P. Mohindra, G. I. Weissmann, V. Divilov, S. A. Hilderbrand, R. Weissleder and J. S. Lewis, Bioconjug Chem, 2011, 22, 2048. 129 R. Pipkorn, W. Waldeck, B. Didinger, M. Koch, G. Mueller, M. Wiessler and K. Braun, J Peptide Sci, 2009, 15, 235. 130 M. Wiessler, W. Waldeck, C. Kliem, R. Pipkorn and K. Braun, Int J Med Sci, 2010, 7, 19. 131 M. Wiessler, U. Hennrich, R. Pipkorn, W. Waldeck, L. Cao, J. Peter, V. Ehemann, W. Semmler, T. Lammers and K. Braun, Theranostics, 2011, 1, 381. 132 S. S.
One major shortcoming of the Cu-promoted Amino Acids, Pept. Proteins, 2012, 37, 1–39 | 11 click reaction is that it works exclusively on terminal alkynes. 81 Even in more complex and challenging environment, in vivo cell culture, click chemistry has found its successful application. The versatility of the CuAAC in living cells was demonstrated by V. Hong et al. in experiments on mammalian cells (CHO, Jurkat or HeLa) labelled eﬃciently in 5 min. 82 The ultimate test of the concept was the non-invasive imaging of glycans in transparent live zebraﬁsh embryos reported by D.
J. E. 2 Peptide arrays. Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analysing interactions in both biological and chemical systems. Relatively short peptides enable the mapping the precise binding sites in such biocomplexes. Peptide array libraries usually contain partly overlapping fragments from the studied protein. The peptide library is attached to a solid support using various techniques such as SPOT-synthesis and photolithography.
Amino Acids, Peptides and Proteins Vol. 37 by Etelka Farkas, Maxim Ryadnov, Jonathan Heddle, Ferenc Hudecz, Shuguang Zhang, Luc Brunsveld, Jason Crain