By Icon Health Publications
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Additional info for Aldosterone - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
4% and 8% NaCI diets. We 36 Aldosterone identified 26 genes that meet this criteria from over 5,000 genes profiled. , aminopeptidase N, serum and glucocorticoid inducible kinase-1 (SGK), directly impact on the renin-angiotensin-aldosterone signaling pathway (RAS). The purpose of this proposal is to test the hypothesis that genes for aminopeptidase N and SGK contribute salt-sensitive hypertension in the Dahl rat. Supportive preliminary data shows corresponding changes in abundance of proteins coded for by these genes in the kidneys and that the genes map to known quantitative trait loci (QTLs) for blood pressure.
Using a combination of mechanical and genetic manipulations in a mouse model of atherosclerosis, we will assess the relative influence on atherogenesis of direct physical changes in blood pressure versus genetic changes in systemic vasoactive mediators or in the factors that affect local responsiveness of vascular tissues. Specific aim (i) is to determine the effects at different stages of lesion development in the carotid arteries of a superimposed mechanical increase (right) or decrease (left) in pressure consequent to aortic arch coarctation.
The goal of this project is to test the hypothesis that SGK modulates ENaC surface expression in part through Nedd4-2 binding and phosphorylation, and to understand the mechanisms involved. In the first specific aim, we will test the hypothesis that SGK phosphorylates Nedd4-2. We will identify the specific residues that are phosphorylated, and will test whether phoshorylation alters Nedd4-2 function. In specific aim two, we will test the hypothesis that SGK binds to Nedd4-2. We will identify the sequences that mediate this interaction, and test the functional role of binding.
Aldosterone - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications