Advances in Physiology, Biochemistry, and Function by A.D. Johnson (Eds.) PDF

By A.D. Johnson (Eds.)

ISBN-10: 0123866049

ISBN-13: 9780123866042

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Extra info for Advances in Physiology, Biochemistry, and Function

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III. BIOCHEMICAL DIFFERENTIATION A. Steroid Synthesis 1. F E T A L TESTIS Biochemical studies in the mid and late 1960s described steroid hormone synthesis in the fetal testes of several species (see Blackshaw, 1970; Hall, 1970). Synthetic activity was found to begin shortly after testicular differentiation at about the time of Leydig cell formation, followed by a sharp rise to maximal levels, and then a decline in activity correlating with the regression of Leydig cells. Studies in the 1970s have provided further evidence of the correlation between Leydig cell appearance and steroidogenic activity (Table II) and have indicated some of the major pathways of steroid metabolism in the fetal testis.

The production of Mullerian Inhibiting Substance by the fetal, neonatal and adult rat. Biol. Reprod. 15, 329. Donovan, Β. , ter Haar, Μ. , and Peddie, M. J. ( 1 9 7 4 ) . Gonadal-pituitary interaction in the foetal and neonatal guinea pig. In "Endocrinologie Sexuelle de la Pe*riode Porinatale" (M. G. Forest and J. ), pp. 1 6 1 - 1 7 2 . INSERM, Paris. Dorrington, J. , and Fritz, I. B. ( 1 9 7 3 ) . Metabolism of testosterone b y preparations from the rat testis. Βiochem. Biophys. Res. Commun. 5 4 , 1 4 2 5 .

And Kelch, R. P. ( 1 9 7 4 ) . Hypothalamic-pituitary regulation of puberty in man: Evidence and concepts derived from clinical research. In "Control of the Onset of Puberty" (Μ. M. Grumbach, G. D. Grave, and F. E. ), pp. 1 1 5 - 1 8 1 . Wiley, N e w York. 32 Bernard G o n d o s Hadziselimovic, F. ( 1 9 7 6 ) . Elektronenmikroskopische Untersuchungen iiber die Entwicklung des Tubulus seminiferus unmittelbar nach der Geburt bis zum vollendeten ersten Lebensfahi. Acta Anat. 9 5 , 2 8 7 . Hall, P.

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Advances in Physiology, Biochemistry, and Function by A.D. Johnson (Eds.)


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