By Karsten Schrör
Written by means of a number one specialist on Aspirin-related study, this is often the 1st complete treaty of the historical past, pharmacological results and medical purposes of 1 of the main winning medications ever.The textual content is written with a large viewers in brain and to be without difficulty comprehensible for clinicians in addition to biomedical researchers and pharmacologists alike. The content material is modern and comprises the newest result of scientific and educational examine, with a balanced view at the disputed homes of this well-known drug.
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Extra resources for Acetylsalicylic Acid
2). 5 mM) in aqueous solution at 42 C. Note the high stability (poor solubility) of aspirin at acidic pH and the significant increase in solubility (rapid degradation) at alkaline pH . 1 N hydrochloric acid (modified after Levy and Leonards, 1966). 1) as well as the increasing absorption in the upper intestine because of markedly improved solubility that also dominates the increased dissociation rate. Methylsalicylate Methylsalicylate is the active ingredient of wintergreen oil from the American teaberry (G.
In the case of ingestion of high (toxic) doses of aspirin, absorption can be additionally retarded and reduced by the formation of concretions (insoluble aggregates), facilitated by the poor solubility of the drug under these conditions. 1). Absorption in the Stomach The data about the extent of absorption of aspirin within the stomach are variable. According to Cooke and Hunt , about 10% of a predissolved 250 mg dose of aspirin is absorbed from an acid solution in the stomach though the main absorption site is the upper intestine.
1979) Die Salicylate. Die Pharmazie, 34, 585–604. , Molony, B. et al. (1994) In vitro dissolution versus in vivo evaluation of four different aspirin products. Drug Development and Industrial Pharmacy, 20, 1711–1723. 76 Blume, H. and Siewert, M. (1986) Zur Qualit€atsbeurteilung von acetylsalizyls€aurehaltigen Fertigarzneimitteln. 1. Mitteilung: Vergleichende Reihenuntersuchung zur pharmazeutischen Qualit€at handels€ ublicher ASS-Monopr€aparate. Pharmazeutische Zeitung, 47, 2953–2958. 77 Siewert, M.
Acetylsalicylic Acid by Karsten Schrör