Eveline S. Litscher, Paul M. Wassarman's A Guide to Zona Pellucida Domain Proteins PDF

By Eveline S. Litscher, Paul M. Wassarman

ISBN-10: 0470528117

ISBN-13: 9780470528112

ISBN-10: 1119044723

ISBN-13: 9781119044727

ISBN-10: 1119044766

ISBN-13: 9781119044765

ISBN-10: 1119044995

ISBN-13: 9781119044994

This e-book presents a coherent, transparent, and uniform presentation of structural, genetic, molecular, and biochemical info to be had for the zona pellucida area protein kinfolk, which effect pathologies akin to infertility, deafness, and melanoma. moreover it:

  • Details information regarding the constitution and serve as of the ZP area in ZPDC-proteins
  • Provides illustrations of the association of ZPDC-proteins, the genes that encode the proteins, and examples of mutations within the ZP area that reason diseases
  • Speculates as to the evolution of the ZP area and power therapeutics for ailments stemming from ZP area mutations
  • Addresses mammalian and non-mammalian systems

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Additional resources for A Guide to Zona Pellucida Domain Proteins

Example text

2 Schematic representation of various features of mZP3. Shown are the positions of the SS (aa 1–22), ZPD (aa 45–302), IHP (aa 170–177), CFCS (aa 350–353), EHP (aa 357–369), TMD (aa 387–409), and CT (aa 410–424). The aa sequence of the CTP of mZP3, from aa 350–424, is shown together with the positions of the CFCS, EHP, TMD, and CT. Note that the IHP is located in the ZP‐N sub‐domain of the ZPD and that the EHP is located between the CFCS and TMD. secretion but is required for cleavage at the CFCS and ensures proper localization and/or topological orientation of nascent ZP proteins so that assembly can take place.

The ZPD of rat ZP4 is 48% identical with and 79% similar to the ZPD of mZP1. 1 marqalrstl wllpsillcf pfclplsgqh vtelpgvlhc glqsfqfavn lsleaespvl 61 ttwdsqglph rlkndsdcgt wvmdspdgfl vleasysgcy vtlegshyim tvgvqeadva 121 ghvagtrqrl ltcplalqgk apdtpsakvC spvpvkerlp Casstisrgd CeelgCCyss 181 eeegadsCyy gntvtshCtk eghfsiavsr dvtspplrld slrlgfrnit tgCdpvmkts 241 tfvlfqfplt sCgttqritg dqamyenelv airdvqawgr ssitrdsnfr lrvsCtysih 301 simspvnmqv wtlppplpkt qpgplslelq iaqdknyssy ygtdayplvk flqdpiyvev 361 silhrtdpsl sllleqCwat pgsnpfhqpq wpilvkgCpy agdnyqtkri pvqkasdvfp 421 shhqrfsist fsfmsagrek qvlggqvylh CsasvCqpag mpsCtviCpa srrrrksely 481 fdnstsissk gpvillqatk dpavmlhkhs gthadsptlw vmglsasmvi tgvlvvsyla 541 trkqr Further Reading Akatsuka K, Yoshida‐Komiya H, Tulsiani DR, Orgebin‐Crist M‐C et al.

For example, female mice that are homozygous nulls for either mZP2 or 3 fail to produce a ZP around growing oocytes and are infertile. Mice that are homozygous nulls for mZP1 produce an abnormal ZP around growing oocytes but are fertile. Several elements of nascent ZP proteins affect their secretion by oocytes and assembly into a ZP. For example, N‐linked oligosaccharides are not required for secretion and assembly of mZP3 but are required for secretion and assembly of mZP2. mZP2 and 3 colocalize in unusually large secretory vesicles derived from Golgi but do not interact with each other inside the vesicles.

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A Guide to Zona Pellucida Domain Proteins by Eveline S. Litscher, Paul M. Wassarman


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